i really dont think in terms of genre, more in individual authors.
the authors i like from the 50s, 60s or 70s are Corwainer Smith, , Ursula LeGuin, Harl Ellison, Larry Niven, Sam Delaney and Brian Aldiss.
I like long series of books like Ringworld and Dune; that whole sweeping epic thing. And i like the bizarre but well executed stuff that guys like Cordwainer Smith and R.A. Lafferty wrote.
As to newer stuff, M. John Harrison, Kay Kenyon. Kay kenyon is halfway through her own trilogy now, check it out. I liked the first two books a lot.
I read shorts anthologies a lot too.
For me, it doesn't get better than Blade Runner. I noticed a few years ago that every new science fiction movie I watch gets an initial appraisal based on how it compares to Blade Runner. I wasn't even doing this on purpose I think, just wishful thinking for more sci-fi noir.
The best are always the ones with engineering, errors, escape, entrapment, and erotica.
If it has a "cookie" in it, it's always better. Be that Ivanova, Rand, Troy, 7 of 9. etc..
The Phillip K. Dick stuff as Blade Runner, Screamers, Imposter usually ... does.
The newest Outer Limits (Canadian) has many as well.
These people knows what sells me.